Mouse Models
MSA/OPCA
Publication
PLP-α-Syn transgenic mouse
Identification
- Research Resource Identifier (RRID)
- MGI:3,604,008
- Causal gene(s)
- Sporadic
- Repeat size or mutation
- Overexpression of human wild-type α-syn
- Animal model
- Mouse
Model Details
- Mouse strain / background
- C57Bl/6
- Type of model
- transgenic
Transgenic Construct
- Transgenic construct: sequence type
- cDNA
- Transgenic construct: details
- Transgene overexpressing human wild-type a-syn
- Promoter: gene
- PLP
Phenotype
- Progression
- progressive
- Hallmark features
- Motor deficits, loss of striatal dopaminergic terminals and DAPP32-positive medium sized projection neurons, increase in soluble α-synuclein species, activated microglia
Source & Publications
- Originating lab / institution
- Ludwig Maximilians University
- Links to publications or public resources
Some fields are restricted to approved researchers. Log in to view them.