Mouse Models
MSA/OPCA
Biobank
A53T α-syn transgenic mouse
Identification
- Causal gene(s)
- Sporadic
- Repeat size or mutation
- WT (M7, M12, M20) and mutant (M83, M91) A53T human α-syn, both hetero- and homozygous
- Animal model
- Mouse
Model Details
- Mouse strain / background
- C57Bl/C3H
- Type of model
- transgenic
Transgenic Construct
- Transgenic construct: sequence type
- cDNA
- Transgenic construct: details
- Expression plasmids (MoPrP.Xho) expressing mutant and WT A53 human a-syn
- Promoter: gene
- PrP
- Promoter: species
- Mouse
Phenotype
- Progression
- progressive
- Hallmark features
- Motor impairments, paralysis, death, intracytoplasmic neuronal α-synuclein inlcusions
Source & Publications
- Originating lab / institution
- University of Pennsylvania School of Medicine
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