Mouse Models
MSA/OPCA
Publication
Thy-1 αSYN mice (Line 61)
Identification
- Causal gene(s)
- Sporadic
- Repeat size or mutation
- WT and mutant (A30P) human α-synuclein
- Animal model
- Mouse
Model Details
- Mouse strain / background
- C57BL/6 × DBA/2F1
- Type of model
- transgenic
Transgenic Construct
- Transgenic construct: sequence type
- cDNA for human α-synuclein expression
- Transgenic construct: details
- wt hα-synuclein cDNA fragment (nt 53–475) were inserted into the mThy-1 expression cassette between exons 2 and 4
- Promoter: gene
- Thy-1
- Promoter: species
- Mouse
Phenotype
- Hallmark features
- intraneuronal inclusions
Source & Publications
- Originating lab / institution
- University of California
- Links to publications or public resources
Some fields are restricted to approved researchers. Log in to view them.