Mouse Models
MSA/OPCA
Publication
CNP-SNCAGFP Tg mice
Identification
- Causal gene(s)
- Sporadic
- Repeat size or mutation
- expressing human αsyn-green fluorescent protein (GFP) fusion proteins in oligodendrocytes
- Animal model
- Mouse
Model Details
- Mouse strain / background
- C57BL6/J
- Type of model
- transgenic
Transgenic Construct
- Transgenic construct: sequence type
- cDNA for human α-synuclein expression
- Transgenic construct: details
- The coding sequence of human αsynGFP or αsyn was cloned into the pBSK plasmid harboring the murine 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) promoter
- Promoter: gene
- CNP
- Promoter: species
- Mouse
Phenotype
- Hallmark features
- α-synuclein inlcusions in oligodendrocytes
Source & Publications
- Originating lab / institution
- Kyoto University
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