Mouse Models
EA1
Publication
Kcna1V408A/+
Identification
- Causal gene(s)
- KCNA1
- Repeat size or mutation
- Heterozygous V408A mutation in the Kcna1 gene
- Animal model
- Mouse
Model Details
- Mouse strain / background
- C57BL/6J
- Type of model
- Heterozygous V408A mutation in the Kcna1 gene
Transgenic Construct
- Transgenic construct: sequence type
- cDNA for murine Kv1.1 locus
- Transgenic construct: details
- A single nucleotide change resulting in the V408A mutation was introduced in the construct with the coding sequence of the murine Kv1.1 locus
Phenotype
- Hallmark features
- Stress-induced loss of motor coordination, increased spontaneous GABAergic inhibitory postsynaptic currents
Source & Publications
- Originating lab / institution
- Oregon Health & Sciences University
- Links to publications or public resources
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