Mouse Models
FXTAS
Publication
TRE-90CGG-eGFP mice
Identification
- Causal gene(s)
- FMR1
- Repeat size or mutation
- Inducible transgenic mouse model that express 90 CGG
- Animal model
- Mouse
Model Details
- Mouse strain / background
- C57BL/6J
- Type of model
- transgenic
Transgenic Construct
- Transgenic construct: details
- Plasmid with eGFP with FMR1 5'UTR, 90CGGs under control of TRE (TRE-90CGG-eGFP) constructs were injected in mice oocytes. TRE-90CGG-eGFP mice were then crossed with the hnRNP-rtTA driver line
- Promoter: gene
- TRE and CMV
Phenotype
- Hallmark features
- Weight loss, premature death, mitochondrial dysfunction, steatosis and apoptosis in the liver
Source & Publications
- Originating lab / institution
- Erasmus Medical Center
- Links to publications or public resources
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