Mouse Models
FXTAS
Publication
Fmr1 (CGG)98 knock-in mice
Identification
- Causal gene(s)
- FMR1
- Repeat size or mutation
- CGG knock-in mouse with 98 CGG
- Animal model
- Mouse
Model Details
- Type of model
- knockin
Transgenic Construct
- Transgenic construct: sequence type
- The mouse (CGG)9 repeat was exchanged for a human (CGG)98 repeat
- Transgenic construct: details
- Construct with mouse Fmr1 promoter where the mouse (CGG)8 was exchanged for a human (CGG)98 repeat
- Promoter: gene
- Fmr1
- Promoter: species
- Mouse
Phenotype
- Progression
- progressive
- Hallmark features
- Cognitive decline and neutomotor disturbances
Source & Publications
- Originating lab / institution
- Erasmus University Rotterdam
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