Mouse Models
SCA11
Publication
conditional Ttbk2 KO (Ttbk2c.mut)
Identification
- Causal gene(s)
- TTBK2
- Repeat size or mutation
- Ubiquitous conditional Ttbk2 knockout
- Animal model
- Mouse
Model Details
- Type of model
- knockout
Transgenic Construct
- Transgenic construct: details
- a conditional allele of Ttbk2 from the European Mutant Mouse Cell Repository (Ttbk2tm1c(EUCOMM)Hmgu) was crossed with a mouse line expressing tamoxifen-inducible Cre recombinase driven by a ubiquitously expressed promoter, Ubc-Cre-ERT2
- Promoter: gene
- Ubc
- Promoter: species
- Mouse
Phenotype
- Hallmark features
- Locomotor deficiencies, thinning of molecular layer of cerebellum, loss of VGLUT2 synapses in cerebellum, neuronal shrinking, altered bergmann glia morphology, loss of neuronal primary cilia
Source & Publications
- Originating lab / institution
- Duke University
- Links to publications or public resources
Some fields are restricted to approved researchers. Log in to view them.