Mouse Models
SCA11
Publication
TTBK2 knockin mice
Identification
- Causal gene(s)
- TTBK2
- Repeat size or mutation
- Heterozygous TTBK2 knock-in of one-base insertion in exon 13 at nucleotide 1329
- Animal model
- Mouse
Model Details
- Mouse strain / background
- C57BL/6J
- Type of model
- knockin
Transgenic Construct
- Transgenic construct: sequence type
- Human TTBK2 exon 13 with an one-base insertion at nucleotide 1329
- Transgenic construct: details
- Knock-in construct containing exon 13 with the one-base insertion of adenosine at nucleotide 1329 within LoxP sites and a puromycin resistance gene. After homologous recombination, Flp recombination removes the puromycin resistance gene.
Source & Publications
- Originating lab / institution
- University of Dundee
- Links to publications or public resources
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