Mouse Models
DRPLA
Publication
Atro-118Q transgenic mice
Identification
- Causal gene(s)
- ATN1
- Repeat size or mutation
- 118Q
- Animal model
- Mouse
Model Details
- Mouse strain / background
- C57BL/6J and SJL/J
- Type of model
- transgenic
Transgenic Construct
- Transgenic construct: sequence type
- Full length human cDNA
- Transgenic construct: details
- Full-length human atrophin-1 cDNA with 118Q was cloned into the NSE transgenic vector with a rat neuron-specific enolase promotor
- Promoter: gene
- NSE
- Promoter: species
- Rat
Phenotype
- Progression
- progressive
- Hallmark features
- Ataxia, tremors, motor defects, nuclear inclusions, somal atrophy, hypoacetylation of histone H3
Source & Publications
- Originating lab / institution
- Morgan-Tan International Center for Life Sciences
- Links to publications or public resources
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