Mouse Models
SCA38
Publication
Elovl5-/- mice
Identification
- Causal gene(s)
- ELOVL5
- Repeat size or mutation
- Homozygous Elovl5 knock-out mice
- Animal model
- Mouse
Model Details
- Mouse strain / background
- C57BL/6J
- Type of model
- knockout
Transgenic Construct
- Transgenic construct: details
- ES cell clone (DTM098) harbors an insertion of gene trap vector 7.9 kb downstream of exon 1 of Elovl5 resulting in knock-out. ES cells were injected in mice blastocyst
Phenotype
- Hallmark features
- Motor coordination impairment, disruption of cerebellar architecture, alterations in cerebellar excitatory presynaptic mechanisms
Source & Publications
- Originating lab / institution
- University of Texas Southwestern Medical Center at Dallas
- Links to publications or public resources
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