Mouse Models
DRPLA
Publication
AT-FL-65Q
Identification
- Research Resource Identifier (RRID)
- RRID: MMRRC_000398-MU
- Causal gene(s)
- ATN1
- Repeat size or mutation
- 65Q
- Animal model
- Mouse
Model Details
- Mouse strain / background
- C3H/B6
- Type of model
- transgenic
Transgenic Construct
- Transgenic construct: sequence type
- Full-length cDNA
- Transgenic construct: details
- Full-length cDNA of atrophin-1 encoding 65Q constructs were ligated into the mouse prion protein promoter vector ensuring expression in neurons throughout the brain
- Promoter: gene
- PrP
- Promoter: species
- Mouse
Phenotype
- Progression
- progressive
- Hallmark features
- Involuntary tremors, ataxic gait, loss of coordination, hyperactivity, increased aggression, lower breeding efficiency, seizures, premature death, atrophin-1 nuclear inclusion bodies
Source & Publications
- Originating lab / institution
- Johns Hopkins University School of Medicine
- Links to publications or public resources
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