Mouse Models
MSA/OPCA
Publication
CNP-α-syn transgenic mouse
Identification
- Causal gene(s)
- Sporadic
- Repeat size or mutation
- Expression of wild-type human α-syn and P301L mutant tau (tauP301L)
- Animal model
- Mouse
Model Details
- Type of model
- transgenic
Transgenic Construct
- Promoter: gene
- CNP
- Promoter: species
- Mouse
Phenotype
- Progression
- progressive
- Hallmark features
- α-synuclein and tau accumulation, limb-twitch phenotype, autophagocytosis of myelin, progressive motor impairments
Source & Publications
- Originating lab / institution
- University of Pennsylvania School of Medicine
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