Mouse Models
MSA/OPCA
Publication
Cre-loxP inducible α-synuclein
Identification
- Causal gene(s)
- Sporadic
- Repeat size or mutation
- Expression of inducible α-synuclein regulated by Cre-loxP
- Animal model
- Mouse
Model Details
- Mouse strain / background
- 129/B6 F1 x C57BL/6J
- Type of model
- Chimeric
Transgenic Construct
- Transgenic construct: sequence type
- cDNA for human α-synuclein expression
- Transgenic construct: details
- Syn cDNA into a Rosa26 chicken β-actin (CAG) promoter-targeting vector for Cre/ER-mediated expression
- Promoter: gene
- CAG
- Promoter: species
- Chicken
Phenotype
- Hallmark features
- α-synuclein accumulation in oligodendrocytes, decreased motor activity
Source & Publications
- Originating lab / institution
- Hirosaki University Graduate School of Medicine
- Links to publications or public resources
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