Mouse Models
SCA37
Publication
Dab1 null mice
Identification
- Causal gene(s)
- DAB1
- Repeat size or mutation
- Dab1 knock-out
- Animal model
- Mouse
Model Details
- Mouse strain / background
- C57Bl6 and 129Sv
- Type of model
- knockout
Transgenic Construct
- Transgenic construct: sequence type
- Targeted disruption of the first 47 codons of the protein-interacting (PI/PTB) domain
- Transgenic construct: details
- Knockout targeting vector contained neomycin phosphotransferase in place of the genomic sequences that contained the first exon of the PI/PTB domain
- Promoter: gene
- PGK
Phenotype
- Hallmark features
- Ataxia, distrubance of neuronal layering in cerebral cortex, hippocampus and cerebellum
Source & Publications
- Originating lab / institution
- Fred Hutchinson Cancer Research Center
- Links to publications or public resources
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