Mouse Models
SCA37
Biobank
Dab1 scrambler (scm) mice
Identification
- Research Resource Identifier (RRID)
- IMSR_JAX:002043
- Causal gene(s)
- DAB1
- Repeat size or mutation
- Spontaneous autosomal recessive mutation in Dab1
- Animal model
- Mouse
Model Details
- Mouse strain / background
- DC/Le (dancer) and C3H
- Type of model
- Spontaneous mutation
Transgenic Construct
- Transgenic construct: details
- spontaneous mutation, with 1.5 kb of intracisternal A particle retrotransposon sequence inserted in Dab1 coding region, leading to abnormal splicing in Dab1 scm homozygotes
Phenotype
- Hallmark features
- Unstable gait, whole-body tremor, disorganized cerebral cortical lamination, cerebellar hypoplasia without foliation
Source & Publications
- Originating lab / institution
- The Jackson Laboratory
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