Mouse Models
SCA37
Publication
Forebrain-specific Dab1 knockout mice
Identification
- Causal gene(s)
- DAB1
- Repeat size or mutation
- Dab1 conditional knock-out
- Animal model
- Mouse
Model Details
- Mouse strain / background
- C57BL/6N
- Type of model
- knockout
Transgenic Construct
- Transgenic construct: sequence type
- Part of the mouse Dab1 cDNA
- Transgenic construct: details
- Targeting plasmid containing exon 3 of the Dab1 mouse cDNA, flanked by 2 LoxP sites and 6.14 kb downstream and 4.5 kb upstream for homologous recombination. Emx1 promoter-Cre recombinase (Emx1-Cre) for specific expression in the dorsal forebrain
- Promoter: gene
- Emx1
Phenotype
- Hallmark features
- No cerebellar phenotype or motor dysfunction, hyperactivity, decreased anxiety-like behavior, working memory impairment
Source & Publications
- Originating lab / institution
- Kobe University
- Links to publications or public resources
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