Mouse Models
FXTAS
Publication
Gfa2-CGG99-eGFP mice
Identification
- Causal gene(s)
- FMR1
- Repeat size or mutation
- Human expanded CGG99 trinucleotide repeat segment
- Animal model
- Mouse
Model Details
- Mouse strain / background
- C57BL/6J
- Type of model
- transgenic
Transgenic Construct
- Transgenic construct: sequence type
- human expanded CGG99 trinucleotide repeat segment specifically in the astrocytes and Bergmann glia
- Transgenic construct: details
- Construct containing human expanded (CGG)99 and a GFP sequence under the Gfa2 promoter ensuring restricted expression in astrocytes and Bergmann glia
- Promoter: gene
- Gfa2
- Promoter: species
- Human
Phenotype
- Hallmark features
- Impaired motor performance on ladder-rung test, improved motor performance on rotarod, intranuclear inclusions
Source & Publications
- Originating lab / institution
- University of California
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