Mouse Models
MSA/OPCA
Publication
MBP-α-Syn transgenic mouse
Identification
- Causal gene(s)
- Sporadic
- Repeat size or mutation
- human α-synuclein cDNA
- Animal model
- Mouse
Model Details
- Mouse strain / background
- C57BL/6 × DBA/2 F1
- Type of model
- transgenic
Transgenic Construct
- Transgenic construct: sequence type
- cDNA
- Transgenic construct: details
- Human α-syn cDNA fragments were ligated with the 5′ upstream region of the MBP cassette; the splice and the polyadenylation signals were supplied by portions of the PLP gene (exon 6, intron 6, exon 7).
- Promoter: gene
- MBP
- Promoter: species
- Mouse
Phenotype
- Progression
- progressive
- Hallmark features
- Premature death, accumulation of α-synuclein inlcusions, astrogliosis, myelin pallor, decreased neurofilament, decreased dendritic density, loss of doparminergic fibers
Source & Publications
- Originating lab / institution
- University of California
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