Mouse Models
MSA/OPCA
Publication
Olig001-SYN mouse model
Identification
- Causal gene(s)
- Sporadic
- Repeat size or mutation
- AAV overexpressing α-synuclein
- Animal model
- Mouse
Model Details
- Mouse strain / background
- C57BL/6
Transgenic Construct
- Transgenic construct: details
- Olig001 capsid has a > 95% tropism for oligodendrocytes and the vectors utilized contained the CBh promoter and bovine growth hormone polyA, controlling the expression of either transgene (human α-syn or GFP as control)
- Promoter: gene
- CBh
- Promoter: species
- Mouse
Phenotype
- Hallmark features
- Neuroinflammation, demyelination, neurodegeneration
Source & Publications
- Originating lab / institution
- University of Alabama at Birmingham
- Links to publications or public resources
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