Mouse Models
MSA/OPCA
Publication
Plp1-tTA::tetO-SNCA*A53T bi-transgenic mice
Identification
- Causal gene(s)
- Sporadic
- Repeat size or mutation
- mutant A53T human α-syn specifically in oligodendrocytes
- Animal model
- Mouse
Model Details
- Mouse strain / background
- C57BL/6JJcl x C57Bl/C3H
- Type of model
- transgenic
Transgenic Construct
- Transgenic construct: details
- Tet-Off system was used to obtain conditional Bi-Tg mice (Plp1-tTA::tetO-SNCA*A53T) overexpressing human A53T α-syn in oligodendrocytes
- Promoter: gene
- Plp1 (tTa) and PrP (SNCA*A53T)
- Promoter: species
- Mouse
Phenotype
- Progression
- progressive
- Hallmark features
- Rapid progressive motor deterioration, ataxia and early death at 30 weeks of age
Source & Publications
- Originating lab / institution
- Kyushu University
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