Mouse Models
MSA/OPCA
Publication
TgM83+/− Snca0/0
Identification
- Causal gene(s)
- Sporadic
- Repeat size or mutation
- human A53T α-synuclein (heterozygous) and mouse α-synuclein (homozygous KO)
- Animal model
- Mouse
Model Details
- Mouse strain / background
- 129/SvEvTac x C57Bl/C3H
- Type of model
- transgenic
Transgenic Construct
- Transgenic construct: sequence type
- cDNA for human α-synuclein expression
- Promoter: gene
- PrP
- Promoter: species
- Mouse
Phenotype
- Hallmark features
- No development of spontaneous illness, neurodegeneration only occurred after addition of MSA brain extracts
Source & Publications
- Originating lab / institution
- University of California
- Links to publications or public resources
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